четверг, 15 марта 2012 г.

29 escape barefoot from flooded Chinese coal mine

BEIJING (AP) — Barefoot and wrapped in white quilts, 29 miners were pulled out of a Chinese coal mine Monday after being trapped by a flood and waiting a day for rescuers to pump out water.

State broadcaster China Central Television showed medics leading out the miners, naked and with their eyes shielded from the light after 24 hours in darkness. Crowds of mine workers, reporters and others cheered as they were taken to ambulances.

Late Monday, all 29 men were in stable condition at a hospital with no serious injuries, Xinhua reported. They may have removed their clothes because wet clothing would have risked hypothermia.

Some 35 miners were initially trapped Sunday …

German industry sees boost from foreign demand

Orders for German machinery were up 48 percent on the year in July, led by strong foreign demand, an industry group said Wednesday _ the latest healthy indicator from Europe's biggest economy.

Still, a separate report on retail sales disappointed expectations, underlining doubts about the strength of domestic demand as the government presses ahead with plans to save billions over the coming years.

The annual rise in machinery orders reported by the VDMA group was the latest in a string of increases that have underscored Germany's export-led rebound.

Orders from abroad were up 54 percent year-on-year in July while orders from inside Germany were up 38 …

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среда, 14 марта 2012 г.

Celebs at Fashion Week: Whooping kudos for a model's broken heel; Gwyneth next to adopt?

Celebs catcalling at Fashion Week? More like giving props to a runway model's smooth recovery.

At Rebecca Taylor show, the runway was decked out in gold sparkles, bordered by the requisite smattering of gliteratti, including actresses Carmen Electra, Amy Smart, and Katrina Bowden _ some of whom whooped and hollered when a model broke a heel and then nonchalantly removed her shoes and continued down the catwalk, the shoes dangling in her hands.

The collection was filled with flouncy sheer floral dresses. Backstage, Stacy London, co-host of the TLC show "What Not To Wear," summed up the look: "They make you wish you didn't have boobs."

Brazil slashes lending rate to 11.25 percent

Brazil's central bank slashed its benchmark interest rate by 1.5 points to 11.25 percent on Wednesday in an effort to keep recession at bay after Latin America's largest economy registered its sharpest decline in years.

It is the biggest single rate cut since November 2003, when the Selic was lowered from 19 percent to 17.5 percent.

It nevertheless disappointed some industry leaders, who said more aggressive steps are necessary if Brazil is to avoid recession this year as the world economic slowdown lowers demand for its key exports.

The bank announced the cut a day after the government reported that gross domestic product contracted 3.6 percent …

UN offers hope for peace in Mideast . . .

Timely intervention by the UN has given world leaders andSaddam Hussein a chance to avoid ghastly warfare over Iraq's invasionof Kuwait. It has also given us Americans time to think, free ofemotional bombast, about what we hope to achieve with our remarkablemilitary mobilization.

The vast majority of Americans believe that when a presidentdisrupts the lives of thousands of military families, includingreservists, and spends more than $2 billion in a few weeks totransport them, their planes, tanks, guns, gas masks and bottledwater to the deserts of Saudi Arabia, the least we can expect is: That Iraq's invaders will be chased out of Kuwait; That Kuwait's previous rulers …

Prince postpones Dubai polo trip amid Arab turmoil

LONDON (AP) — Britain's Prince Harry has postponed a planned polo visit to Dubai on March 19 amid escalating unrest in the Arab world.

Harry's office at St. James's Palace in London said Friday the prince felt it would be "insensitive for him to participate in a sporting event at a time when there are matters of greater priority to focus on …

Clinton: US, India to join hands on climate change

India and the United States can jointly devise a breakthrough plan for fighting climate change that will generate massive new investments and millions of jobs, U.S. Secretary of State Hillary Rodham Clinton said Sunday.

She also assured India that while the U.S. wants it to do more to fight climate change, Washington will never impose conditions that would limit India's economic growth.

Clinton, who arrived in India late Friday, said that devising a comprehensive and strategic approach for achieving a clean energy future is an important topic of her three-day trip.

"I am very confident the United States and India can devise a plan that will dramatically change the way we …

A Gun Under Every Coat? // States Ponder Looser Concealed-Weapons Laws

John Whetsel of Choctaw, Okla., doesn't see a need for everyonein his hometown to be strapping on a firearm under his or her coat.Yet it is likely the Oklahoma Legislature will allow them to do justthat.

To say that there should be relaxed laws on who can carryconcealed weapons "means we've given up on our society," said theWhetsel, police chief for the town of 7,500.

In El Paso, Texas, elementary school nurse Mikey Voorhees hasplayed citizen lobbyist at the Texas Statehouse, urging lawmakers toallow her and others to carry hidden handguns for self-protection.

Years after she fended off eight men at a deserted campsite witha handgun, Voorhees contends …

Kahne wins pole at Kansas Speedway

KANSAS CITY, Kan. (AP) — Kasey Kahne and Paul Menard swept the front row in qualifying for Sunday's race at Kansas Speedway, one of their last for Richard Petty Motorsports.

Kahne drove his Ford to a quick lap of 174.644 mph on Friday, earning his third pole of the season. Menard ran 174.469 mph on the 1.5-mile tri-oval. Both are leaving RPM after the season.

"To me it shows that myself and Paul and our teams are still really interested in running strong and not backing down just because we have other things we're going to do in the future," Kahne said. "At the same time, it shows that RPM is giving us great race cars. We still have great packages. We just need to put it …

Strike halts Hyundai India production for 2nd day

Police cleared dozens of workers occupying a Hyundai Motor plant as a strike stopped the automaker's Indian production for a second day, the latest in a series of union battles that have pushed the nation's No. 2 carmaker to move some production to Turkey.

Hyundai spokesman Rajiv Mitra said police removed the workers from the factory shortly after midday Tuesday. The company is awaiting the outcome of talks between management and union leaders, which are being brokered by state labor officials, before deciding when to resume production.

Mitra said he hoped that would happen by day's end. "No one wants to lose this kind of money," he said.

Palazuelos ready to step into derby cauldron

New Hearts midfielder Ruben Palazuelos insists he has the big-match experience to cope with making his debut in tonight's Edinburghderby.

The 24-year-old signed a two-year deal with the option of afurther two years at Tynecastle last week.

Palazuelos may be one of a number of players making theircompetitive bows as Hearts attempt to increase the pain for Hibs bossJohn Collins, who has been forced to sell several top players sincetaking over.

The Jambos also signed Lithuanian pair Andrius Ksanavicius andRicardas Beniusis on loan from Kaunas, while Hibernian have seven newplayers in the frame including former Motherwell midfielder BrianKerr.

But Palazuelos believes he can cope with the intensity of theoccasion having played in two fiercely-fought derbies in Greeceearlier this year.

The central midfielder spent the second half of last season onloan at Aris Thessaloniki.

"I played in two derbies in Salonika against PAOK and it is avery, very intense rivalry between the two clubs and the two sets offans. On both occasions the ground was completely full and there wasa lot of intensity and aggression, but that is something you have gotto live with."

Palazuelos hopes he can revel in the atmosphere of a packedTynecastle tonight and get his Hearts career off to a perfect start.

"The game is one of the games that are lived very intensely. Weare hopefully able to live it and win it."

Black books galore! Continues to build bridges to African American literature

As a little girl growing up in a small town in upstate New York, I never experienced the joy of reading children's books by African American writers. The books I was exposed to featured characters with blond or brown hair and blue eyes with names like Dick, Jane, and Sally. But thanks to Black Books Galore!, my two sons and literally thousands of other children of color can choose from a rich assortment of books by African American writers and illustrators -- books that include characters and storylines that reflect the totality of the black experience. They can delve into books about the adventures of black cowboys, read African folktales and legends, or peruse books that educate them about slavery in America. They can further indulge in biographies of modern sports heroes and unsung heroes of the past, and revel in tales of everyday life in a South African township.

Black Books Galore!, a children's book service based in Stamford, Conn., is run by Toni Trent Parker, an energetic mother of three, fervent book lover, and is a medium for children to experience the joys of literature for and about them. As president of Black Books Galore!, Parker arranges festivals three times a year that draw thousands of children of all ages, along with parents, grandparents, teachers, and entire communities gathered together to celebrate children's books. Black Books Galore! is dedicated to identifying and distributing fine African American children's literature. "There's such a wealth of rich literature in African American children's books and I want kids, both black and white, to be exposed to this treasure trove of literature. That's what keeps me going," Parker enthuses.

At each festival, BBG! sells 300 to 500 titles of every description. Admission is always free and the festivals are held on a Saturday or Sunday so that the entire day can be dedicated to the enjoyment of books. This year's festival took place April 24 at the Cathedral of St. John the Divine in New York. Celebrities such as Doug E. Doug ("Cosby"), Buck Williams (Former New York Knick), and Teresa Weatherspoon (WNBA, New York Liberty) were on hand to spin tales for the children, as well as authors and illustrators Yvonne Buchanan, Gavin Curtis, Leo & Diane Dillon, Patricia Hinds, Wade & Cheryl Hudson, Andrea & Brian Pinkney, and James Ransome. This was the first BBG! festival to be sponsored by leading children's book publishers, and partial proceeds will benefit Harlem Reads, Harlem Writes, a program that promotes literacy in the community.

Black Books Galore! was created seven years ago by a trio of concerned mothers, Parker, Sheila Foster, and Donna Rand, who were frustrated in their search for books for their children that depicted persons of color. With little business acumen but a firm passion for connecting books and kids, the moms organized book fairs for area schools, churches, and community centers. Since the inception of BBG!, they've coordinated festivals in New York, Chicago, Los Angeles, North Carolina, and Washington, D.C., always inviting celebrities to read and authors to sign books. BBG! helps children see that books can be fun and entertaining as well as educational. Today Parker runs the store solo and wants kids to think, "If he can write a book, or if she can do illustrations, so can I."

Parker herself is the author of Black Books Galore! Guide to Great African American Children's Books (Published fall 1998 by John Wiley & Sons. Compiled by Parker, Foster, and Rand). The book is a natural offshoot of the festivals, and features a listing of 700 recommended books for children of all ages.

After nearly a decade of involvement with the festivals, Parker has spotted several positive trends such as picture books featuring historical events like The Story of Ruby Bridges by Robert Coles (Scholastic, 1995). And she likes books like The Day Gogo Went to Vote by Elinor Batezat Sisulu (Little, Brown, 1996) because they educate children while entertaining them. Another book she finds trendsetting and instructive is White Socks Only by Evelyn Coleman (Albert Whitman, 1996). Parker is also excited by picture books that feature less prominent African American heroes like Richard Wright, Benjamin Banneker, and Zora Neale Hurston. "We have lots of children's biographies of Martin Luther King Jr., Rosa Parks, and Harriet Tubman, but we need to also teach our children about the other legends," she points out.

This year Parker will introduce BBG! to cyberspace when her Web site (www.blackbooksgalore.com) is unveiled at the end of May. In addition to featuring a broad list of children's books that can be purchased online, Parker will provide information on BBG! and its schedule of events and activities. She also plans to include a unique slide show presentation on the Web.

As she continues to build on the BBG! brand name, Parker has several ideas for the future -- from BBG! videotapes of author readings to a BBG! wall calendar spotlighting a book a month for display in homes, schools, community centers, or even church bulletin boards.

One thing is certain: the opportunities are endless, as is Parker's energy, enthusiasm, and passion for children's books. And even though planning and hosting the BBG! festivals involves a considerable amount of work, Parker wants folks to know that above all, "It's fun...I truly enjoy it and I know BBG! is having an impact on the kids."

Photograph (Toni Parker reads to her niece)

вторник, 13 марта 2012 г.

Planes for Peace

Youth fold paper planes at Assembly as a protest against Canada's militarization

These paper planes may not fly themselves to Ottawa, but even so they will deliver a message to Stephen Harper - spend less money on war. Throughout Assembly youth folded paper planes, covering them with words or pictures of peace, and then sent them off to the capital with youth pastor Sarah Johnson.

The act of folding paper is "something really simple," said Renae Friesen from Altona Bergthaler Mennonite Church, but in big numbers it could make a difference. And big numbers they achieved; by the end of the week over 1,000 planes were constructed, some including messages like "this plane doesn't fly, and neither should yours."

Though the teens hope that Canada's leaders will consider their message, they are also realistic about the immediate impact. "It's not like they're going to return [the fighter jets]," said Micahela Epp, from Altona Bergthaler, but if we don't do anything they won't know that we disagree.

Epp, Friesen and Benita Bage felt that it was important to get involved in politics like this because their future is at stake, and if they don't work for change now they will have to live with the consequences when they're older. The teens suggested that rather than the government spending money on war, they should spend it on things like education, social programming and foster care.

According to Kathy Giesbrecht, associate pastor at Home Street Mennonite Church, the government should be using the billions spent on conflict to establish a Department of Peace, a movement with chapters in over 30 countries (www.mfp-dop.org). Creating a peace department wouldn't mean doing away with defence entirely, "we're not naive," Giesbrecht said, there is conflict in the world but we think they "might want to experiment with some solutions" and find some that don't include violence.

Though Giesbrecht thinks the government tends to write off pacifists, she said she has hope "my own government and the world can live in different ways in my lifetime."

[Sidebar]

Throughout the week in Waterloo, youth folded and decorated planes to send a message of peace to Ottawa.

[Sidebar]

Anika Bartel, Trang Tan, Eric Siemens and Fiona Mo fold and decorate paper to be sent to Ottawa with a message of peace.

[Author Affiliation]

EMILY LOEWEN

Young Voices editor

WATERLOO, ONT.

Obama supports SKorea response to ship incident

The White House said Monday that President Barack Obama "fully supports" the South Korean president and his response to the torpedo attack by North Korea that killed 46 South Korean sailors.

In a statement, the White House said Seoul can continue to count on the full backing of the United States.

The administration said it endorsed President Lee Myung-bak's demand that "North Korea immediately apologize and punish those responsible for the attack, and, most importantly, stop its belligerent and threatening behavior."

Lee said Monday that South Korea would no longer tolerate the North's "brutality" and said the repressive communist regime would pay for the surprise March 26 torpedo attack.

He also vowed to cut off all trade with the North and take Pyongyang to the U.N. Security Council for punishment over the sinking of the warship Cheonan.

The attack was South Korea's worst military disaster since the Korean War.

Speaking earlier in Beijing, U.S. Secretary of State Hillary Rodham Clinton said the North must be held accountable and she is pushing to get the support of China, North Korea's top ally, for diplomatic action.

PLANTS AND PROJECTS

Solvay Branches Out in Sulfone Specialty Polymers

Solvay Advanced Polymers, LLC (Alpharetta, GA; www.solvay-advancedpolymers.com) is planning to construct a sulfone polymers plant that will nearly triple the company's existing polyethersulfone (PES) capacity. The facility, which is expected to cost around $50 million, is slated to be commissioned in 2006, at which time it will produce the full suite of Radel PES and polyphenylsulfone (PPS) products.

Polypropylene Production Site Slated for Middle East

Sahara Petrochemical (Riyadh, Saudi Arabia; www.zamil.com) and Basell NV (Hoofddorp, Netherlands; www.basell.com) have signed an agreement to construct a 450-kton/yr polypropylene plant and propane dehydrogenation unit in Al-Jubail, Saudi Arabia. The facilities will be operated by a joint venture that the partners plan to establish this year. This agreement includes a license for Sahara Petrochemical to use Basell's Spherizone process, which features a multi-zone circulating reactor system that creates polypropylene. The polypropylene will be marketed globally by Basell. The propane dehydrogenation unit will feature UOP's (Des Plaines, IL; www.uop.com) Oleflex, a catalytic dehydrogenation technology that makes propylene from propane and isobutylene from isobutane. Startup of the new plant is targeted for the end of 2007.

BP to Close U.S. Linear Alpha Olefin Production Plant in Texas

BP Plc (London, U.K.; www.bp.com) is planning to shut down its linear alpha olefin (LAO) production facility in Pasadena, TX, by the end of this year, cutting its global LAO capacity by 500,000 metric ton (m.t.)/yr. The closure is the result of sluggish product demands, high feedstock and energy costs and overcapacity of LAO in the marketplace. This abundance is attributed to recent plant expansions by BP and other producers, which have added over 450,000 m.t./yr to global LAO output. BP will continue to supply customers with LAO from its Joffre, Alberta, Canada, and Feluy, Belgium, facilities, which have respective outputs of 250,000 m.t./yr and 300,000 m.t./yr.

Degussa's Catalyst Center Offers Cradle-to-Grave Manufacturing

Degussa AG (D�sseldorf, Germany; www.degussa.com) has opened a new catalyst development center that accommodates R&D through production activities for homogeneous, heterogeneous and biological catalysts. The $12.6 million facility, located at Degussa's Hanau-Wolfgang site near Frankfurt, houses the Biocatalysis Service Center, the Synthesis and Catalysts business unit, and a new internal start-up company called Degussa Homogeneous Catalysts. These operations will handle projects ranging from screening for the best substance to catalyze a particular reaction, to developing the manufacturing process, to supplying that catalyst for commercial use. Products can currently be supplied in kilogram-scale quantities.

New Akzo Nobel Factory Boosts Coatings Coverage in Vietnam

Just seven months after construction work began on a 40,000-m^sup 2^ greenfield site in Dong Nai, Vietnam, for Akzo Nobel N.V.'s (Arnhem, the Netherlands; www.akzonobel.com) new decorative coatings plant, paint has officially started to flow off the production line. Operated by the company's Decorative Coatings International (DCI) business, the factory is expected to increase Akzo Nobel's coatings market share in that region and position the firm to launch production of its full product range of decorative coatings by yearend.

[Sidebar]

BASF Unveils Coatings Plant in Monterrey, Mexico

BASF AG's (Ludwigshafen, Germany; www.basf.com) coil coatings customers in the Nuevo Leon, Mexico, region will benefit from faster product delivery and an enhanced level of service, thanks to a new paint-on-demand (POD) manufacturing plant in Monterrey. This facility, a satellite operation of BASF's site in Tultitlan, Mexico, will provide customers with small-batch (1,000 L or less) production and delivery of products, as well as laboratory and technical services. A variety of technologies will be used to meet customer specifications for a wide range of products (e.g., Fluoroceram PVDF coatings and Superl SP II ULTRA-Cool siliconized polyester - a "cool" coating that offers high reflectivity in a wide range of colors).

Phase 3: Clinical development

Time: 2-4 years

Cost: $10-500 million

Scale: kilograms of product (1,000 - 5,000 patients)

Success rate: 80%

During phase 3 trials, a company verifies the efficacy of its drug and monitors 1,000,000 patient volunteers for adverse events during long-term use. Less than a quarter of INDs make it all the way through phase 3 clinical trials, but the majority of products that begin phase 3 will make it through with their development programs intact.

The number of human subjects involved in a phase 3 study depends on the disease being studied. "Orphan drug status" granted by FDA means a therapeutic will ultimately treat a patient population of 200,000 or fewer, and such drugs receive special regulatory treatment because they will never be "blockbuster" sellers for the companies developing them. Without a large market awaiting the product, a company must have another kind of incentive to move forth with it, so regulatory agencies try to help lessen the cost of development for orphan drugs.

Phase 3 trials are expensive: Clinical monitoring of patients can include X-rays, blood tests, and other laboratory studies in addition to physician fees and required hospitalizations. Whereas classical pharmaceuticals go through two or more phase 3 trials, biopharmaceuticals usually require only one because a certain baseline efficacy is assumed based on the fact that living things make the chemicals themselves. A pre-BLA (biologics license application - described in the next chapter) meeting with FDA is optional at the end of phase 3.

Regulatory matters. While phase 3 studies are going on, preparations are made for submission of the BLA (for most biotech drugs) or the new drug application (NDA). BLAs are reviewed by FDA's Center for Biologics Evaluation and Research. NDAs are reviewed by the Center for Drug Evaluation and Research, which handles classical, small-molecule drugs and a small number of biotech drugs. Hormones (such as insulin and estrogen) are traditionally reviewed by CIDER, even through they are manufactured through biologic means. Biologics were traditionally more difficult to purify and characterize; modern biotechnology has resolved some of those challenges, but for now even well-characterized biologics are regulated separately from classical drugs.

In some cases, a biopharmaceutical company can get permission from FDA for expedited review. That fast track review allows a company to combine phase 2 and 3 clinical trials, shortening the approval process for new medicines that address serious and life-- threatening diseases. Such priority status gives FDA six months to review a BLA, whereas the time allowed for a standard application is 10 months.

Key Departments

The analytical laboratory is now performing continual methods validation and product characterization, testing for stability and consistency, and further refining the drug formulation. Chronic toxicology studies continue, and the animal laboratory is looking for reproductive side effects. That includes determining whether the drug product transfers across the placenta to a developing fetus and whether it may find its way into an animal's milk, in addition to looking at general effects on male and female fertility. Carcinogenicity studies in animals can take up to three years and may require several million dollars of investment, so they don't begin until a drug has reached the final stage and shown itself to be a good candidate for eventual approval.

The manufacturing department needs to have a good process under way by this point. The priority now is summed up as final formulation, fill-and-finish. If the product comes from the milk of transgenic mammals, it will have been scaled up to the species best able to produce the volume needed for the eventual market - goats, sheep, or cows, for example. Corn or tobacco plants may be used to produce the drug. Most biopharmaceuticals are produced by bacterial fermentation or eukaryotic cell culture (using cells from multicelled animals or yeasts). Such cell lines should be well characterized and optimized by this point. Production, validation, SOPs, and regulatory matters are increasingly crucial.

Whether in the sponsor company or at a CRO or CMO, the following departments and functions are involved in phase 3 trials: analytical laboratories, QA/QC, GMP compliance, regulatory affairs, manufacturing and production, and clinical development.

Equipment and Methods Used

Development staff understand that their project may die in phase 3 (although its chances have improved with each successful step through the development process). But they also know that if the company receives a license to market the drug, management will expect to have a full-scale manufacturing process ready to go as soon as possible. The biopharmaceutical company may have been surviving up to this point on venture capital and/or partnership money alone, and those investors will be looking for sales returns.

The manufacturing department continues to refine its production process, trying to find a balance between speed and efficiency in fill-and-finish. If liquid formulations go into vials or ampules too quickly, bubbles can form. Foaming is dangerous, causing delicate proteins to unfold or break. Because (as stated previously) proteins' actions depend on their three-dimensional structure, such denaturation destroys a protein's ability to perform its intended function in the body.

For the biopharmaceutical company's manufacturing and production department, the best choice might be to freeze-dry the liquid protein formulation into powdered (lyophilized) form. That in itself brings up a whole new set of problems. Those who administer the drug will have to reconstitute its formulation to prepare the injection.

Critical Concerns

Regulatory affairs personnel are now doing preparatory work on the BLA submission. The QA/QC department is ensuring that the experimental drug given to patient volunteers is truly the drug's pure and final form. If, during scale-up of the manufacturing process, significant changes were made between phase 1 and phase 3, the company may have to establish equivalency of formulations and processes. That, of course, means more testing and analysis.

If a product succeeds through phase 3 trials, it will need to go into full-scale production for the market (pending FDA's decision on the licensing application, of course). Often the manufacturing process is transferred from the smaller pilot plant to the large-scale facility in time for phase 3 trials, but if not, the transfer will begin during phase 3. Equipment for full-scale production must be formally qualified and instruments appropriately calibrated according to GMP requirements and industrial standards. Process validation must demonstrate comparability of the product manufactured to that made in the pilot-scale plant and that the process operates within the parameters and specifications that were set early on. Cleaning (and thus cleaning validation) has become a very important consideration, especially if the product will be made in a "multiuse" facility where other biologics are also made. Cross-contamination between processes must be prevented. Multiproduct facilities require more extensive validation efforts, but the cost is usually offset by using the equipment, suites, and utilities more efficiently than if the facility were devoted merely to a single manufacturing process.

Often during process transfer, validation studies are performed by process scientists with production personnel alongside to learn; production staff in training do qualification work, observed and assisted by development personnel. By now the studies should not be as complex as those run earlier, serving mainly to confirm operational parameters and verify the success of transfer. Not only is each section of the process tested, but the final system as a whole will require test runs as well.

Guidance

GMPs are required by law in any biotech plant making drug products for human use, even in early clinical trials. By phase 3, GMP compliance should be at its most rigorous. A regulatory affairs executive has described several significant differences between pre-- GMP and fully GMP-compliant companies. One such difference is that, in a GMP company, the number of people involved in production, testing, support, and administration at least equals - and may be twice as great as - the number of research scientists, who far outnumber them in a young company still primarily involved in early development.

Manufacturing and support personnel are not allowed to develop off-the-cuff solutions to problems that arise. They must follow accepted, validated, approved methods and standard operating procedures. Changes and modifications must be approved through official means. GMP regulations require documenting all work done, all deviations and investigations into them, all decisions and review (sometimes with formal validation protocols), all data collection and analysis, and all reporting. Communication is much more formal in a GMP-compliant company than in a research organization. That is the only way for the company to be able to back up its claims during subsequent reviews or FDA inspections.

On the Horizon

As a biopharmaceutical company looks forward to putting its product on the market, it must consider the eventual scale of production. If that scale is large enough, transgenic technology may provide the best answer. Several drugs now in clinical trials are produced in the milk of transgenic rabbits, sheep, goats, or cattle. And there are other amazing transgenic proposals - all still experimental, at this point. A couple of companies will offer therapeutic proteins from the eggs of transgenic hens. Potatoes are producing vaccines for E. coli and cholera, Tobacco plants are making human hemoglobin in their seeds and roots. Transgenic corn is producing therapeutic proteins. And a California company is working toward other plants that make human antibodies. Development of transgenic plants may advance the concept of plant cell culture as a production means, as well.

Transgenics presents a number of challenges to drug developers. It is true that the technology can offer much higher yields than more traditional biotech methods. But questions remain about how to purify a pharmaceutical protein from a mixture containing many other proteins and fatty acids like those present in milk. Purification from plant tissue may be less problematic. Humans have far fewer pathogens in common with plants than with mammals. But the herbicides and soil components that are familiar to farmers might present a problem for injectable drugs, which must be very pure to be safe.

The 1997 announcement of Dolly the cloned sheep brought the idea of cloning into the public spotlight. The nuclear transfer research that led to her creation aims to produce transgenic animals faster for protein production. But the technology raises ethical questions. Now the concept of transgenic species - particularly genetically modified food and plants - is the subject of heated debate all over the world. Those and related issues need to be resolved before transgenics can become a mainstream technology.

[Sidebar]

21 CFR Part 11: Drug Development in a Digital Age

[Sidebar]

Since 20 August 1997, FDA has considered electronic records to be equivalent to paper records and electronic signatures to be equivalent to traditional handwritten signatures if certain criteria are met. That means that INDs, BIAs, and NDAs, among others can be submitted electronically. However, validation is required for computer systems that are used to create, modify, maintain, archive, retrieve, or transmit data intended for submission.

[Sidebar]

You might think that electronic filing would be easy; after all, computers have been a staple of the business and scientific world for more than two decades now. But security and compatibility between networks and operating systems have not been simple to achieve. Electronic filing of large, sensitive documents like drug marketing applications requires dependable electronic signatures and cross-platform file formats. Old computers and digital lab equipment, called legacy systems, must be maintained if records were created on them, and those records must be retained securely so that regulators can instantly reconstruct analyses. Regulators want to be able to trace final results back to the raw data using the same tools the user had when the data were generated.

[Sidebar]

Security is a big concern in computer system validation and must ensure authorized access only, unique user IDs and passwords, forced log-offs for long inactive periods, local date/time stamps, and user-independent, computer-generated, timestamped audit trails. Data integrity and confidentiality is required for all computerized laboratory and production equipment.

[Sidebar]

The Part 11 rule applies to good laboratory practices (GLPs), good clinical practices (GCPs), and current good manufacturing practices (CGMPs), collectively referred to as GxPs. It applies to everything regulated by FDA, including medical device manufacturers, blood banks, foreign companies, and pharmaceutical and biotech production. The first warning letters and FDA 483s for electronic record/electronic signature violations were issued in November 1997 and are still being issued, but Part 11 is now appreciated, accepted, and supported by most of the industry.

In Business--and Philanthropy--His Goal is ROI

Harold Grinspoon has a definite economy with words.

He summons them slowly and carefully, and expends them as if they were a natural resource not to be wasted. But he's efficient, and he gets his points across in a remarkably succinct fashion.

Indeed, when asked about his basic approach to commercial real estate, a realm in which he has amassed a fortune and secured a reputation as a master at identifying undervalued properties and seizing opportunities that others may not recognize, he paused and said simply, "it's all about getting return on investment."

Grinspoon, founder and CEO of West Springfield-based Aspen Square Management, would use these same words again later when asked about his thoughts on another area in which he's known internationally--philanthropy--and how he's chosen the directions for the more than $100 million he and his wife, Diane Troderman, have given to date.

"When you're making the money, you want return on investment, and when you're giving it away, you want return on investment," he said of work that has come in two primary areas--promoting the Jewish religion and culture (a broad challenge to which most of his efforts have been directed) and inspiring entrepreneurship--and is carried out through the Harold Grinspoon Foundation, created in 1993, and the Harold Grinspoon Charitable Foundation, launched in 1986.

And while he acknowledges that, in both realms, measuring ROI is a much more subjective exercise than in business and especially real estate, he believes he's making a difference.

His PJ Library, as it's called, has given away more than 2 million Jewish-themed children's books to families across the country since it was launched in 2005. Born from his deep concern about the impact of assimilation on Jewish identity and inspired in many ways by Dolly Parton (more on that later), it uses the tagline "building a stronger Jewish people, one book at a time."

"My thought is that the Jewish people are in trouble," he said, then pausing for effect. "There's a roughly 50% intermarriage rate, and only 28% of the kids from these marriages grow up being Jewish. You don't have to be a genius to figure out what those numbers mean. So we provide Jewish books to Jewish kids about Jewish culture."

Meanwhile, his so-called Entrepreneurial Initiative (EI) was launched in 2002 with the goal of inspiring more young people to consider entrepreneurship as just one of many career paths they can choose.

"I wanted to encourage people to become entrepreneurs," he said of his inspiration for the program. "People become doctors, lawyers, and accountants ... I want them to know that they can also become entrepreneurs."

As he talked about his endeavors in the promotion of entrepreneurship, Grinspoon again demonstrated both his frugality with words and his ability to get to the heart of the matter quickly and directly.

When asked what he says to the young people he meets through his broad initiatives, he said simply, "I just applaud them."

For this, the latest installment of its Profiles in Business series, Business West talked with Grinspoon about how he's made his fortune, but mostly about what he's done with it, a pattern of giving back that is both inspirational and thought-provoking.

Buy the Way

But first, a few words about pilates.

Grinspoon, soon to turn 82, starts each day with a one-hour workout in this discipline designed to increase strength, flexibility, and control of the body. He said he's been doing this for years, and that the routines, which start promptly at 6:30 with an instructor, get each day off to a solid start.

From there, he moves on to 15 minutes of aerobic dancing, meditation for another 15 minutes, and then a vigorous, hour-long, 4.2-mile walk that takes him down along the Connecticut River; sometimes he'll conduct interviews or handle some business while doing so. By 10, he's in the office, dedicating 90% of his time, by his estimates, to his philanthropic endeavors.

As for the company, "42% of it is owned by the key employees," he said. "They run the business."

This is the enterprise that he grew from what could only be described as very humble beginnings--more specifically, the purchase some 55 years ago of a two-family home at 331 Springfield St. in Agawam (yes, he still remembers the address), accomplished with some financial help from an in-law.

"I think I paid $10,500 for it," he recalled. "I rented out one side to someone who paid me $75 a month, and I rented out two rooms for $10 a week, and I stayed in another room. That's how I got started.

"We used to do a lot of bird-dogging--calling people up to see if they wanted to sell property," he continued, while discussing how his venture grew from that inauspicious start. "There was one guy, who must have been elderly--he lived in Florida--who owned 11 properties in the Springfield area that he bought from the banks during the Great Depression and he wanted to sell. I think I gave him a couple thousand dollars down, and he took back the mortgages with a partial-release clause; that was a big start for me."

He and his partners would go on to acquire dozens of multi-family properties in Western Mass.,--mostly from other opportunists who had snapped them up during the depression and were now ready to sell off their portfolios--and eventually take his enterprise from local pursuit to national giant. Rather than talk at length about the growth curve, he took out a piece of paper and drew it instead; the line progressed at a very modest upward angle for several inches, then ticked up slightly for an inch or so, and then shot up at something very dose to 90 degrees, depicting Aspen Square's explosive growth in the '80s and '90s.

There are currently about 16,000 units in the portfolio, just over half the peak volume accumulated by mid-2006. That's when Grinspoon starting selling off properties after concluding presciently that some disturbing trends were soon to force the bottom to fall out of the nation's real-estate market and the bubble to burst.

"I saw it coming ... people who couldn't pay their rent were buying houses--act across the country that was happening," he said of the lending patterns that would eventually trigger the worst economic downturn since the Great Depression. "The U.S. government did a great disservice to the American people because they underwrote these mortgages knowing that people couldn't pay them. The U.S. government is responsible for this bust; it was all caused by real estate.

"In the old-fashioned days, when you went to a banker to buy a house, he'd want to see if you could pay for it," he continued. "Then, we went into collateralized lending where the banks and the mortgage brokers who sold this stuff up couldn't care less; no one had any concern about who was going to pay the loan back."

Getting Down to Business

Grinspoon said his success in real estate is a manifestation of entrepreneurial drive he believes he's always possessed. It was evident at Marlboro College in Vermont, from which he would eventually drop out, but not before gaining some valuable lessons in how to earn a dollar or two with some imagination and desire.

"There were 48 kids there, and there was no place for them to wash their clothes," he recalled. "I found this old Maytag washing machine with a ringer, and I put a quarter coin box in there; they paid for the electricity and the hot water ... there was no overhead. That was my first venture into entrepreneurship."

But, obviously, not his last. He would later sell ice cream out of a cart--he has something approximating that vehicle in the backyard of his home in Longmeadow--and later manage two fleets of ice-cream trucks. He would go on sell paper goods, among other jobs, before transitioning into real estate.

Today, his foundation is focusing some of its time and considerable resources to the task of promoting entrepreneurship among young people, with the broader, long-term goal of creating companies and jobs in a region that has a long history of organic growth.

Grinspoon said he and Diane often debate the subject of entrepreneurship and whether this is an innate talent or something that can be taught and encouraged. He falls into the latter camp, and stresses development of what he calls "creative skills," or the art and science of being able to see opportunities.

The EI has two main programs, both designed to encourage and applaud fledgling entrepreneurs. The first is something called the Spirit Award, so named because it is given annually to an individual who demonstrates entrepreneurial spirit. This year, it went to Hendelee Wilson, who has spent the past several years developing a product that will enable users to employ a cell phone or other mobile device to get a quick diagnostic check of their automobile, and is close to having it ready for the marketplace.

The second initiative is an annual elevator-pitch competition involving representatives of all the area colleges and universities. This year's winner was Lindsey Weaver from Bay Path College, who pitched her idea for a business called Polar EYES, a soft contact lens that provides outdoor UV protection, the power of polarization, and can transition from light to dark

At the annual awards ceremony, where the pitch contest was conducted, Grinspoon spent the night talking with students and providing doses of encouragement. Nearly a decade after starting the EI, he says it's achieving its main goals.

"Some of the people have gone on and done quite well," he said of participants in the programs. "The most important thing we do is support them; we support them and let them know that there's a big world out there and many opportunities for them. People ask me if there's the same opportunity in real estate today as when I started, and I say yes."

While measuring the impact of such initiatives is difficult, Grinspoon believes he is indeed getting return on his investment. And he feels the same away about his many projects to promote the Jewish religion and culture, including the PJ (short for pajamas) library.

The program, which gives away 75,000 books a month in collaboration with philanthropic partners in 145 cities across North America, is modeled after Dolly Parton's Imagination Library, which gives away 350,000 books a month through 650 philanthropist partners, including Grinspoon.

He showed BusinessWest a number of the titles distributed regularly, including In the Month of Kisliv, a Story for Hanukkah; New Year at the Pier, a Rosh Hashanah Story; The Brothers Promise, a story about Tzedakah, the Hebrew word meaning 'righteous giving'; and Let My People Go, which uses rhyming phrases to help children (age 7 is the specific target) better understand the events leading up to the Israelites' departure from Egypt.

Individually, and collectively, the books are designed to entertain and enlighten, said Grinspoon, and the program itself was created to draw attention to a problem and involve people in the solution. This is the common denominator for many of the Grinspoon Foundation's programs, which involve challenge grants to foster involvement and broader philanthropy.

Taking things one step further, one initiative, the B'nai Tzedek Teen Philanthropy Program, engages teens ages 12 to 18 to actively participate in philanthropy through fund-raising and fund distribution as well as community-service and social-action projects.

Overall, Grinspoon said that his pattern of philanthropic giving has pretty much mirrored that line he drew charting the growth of his business ventures. Most of it has come fairly late in life, and involves much more than simply writing checks.

"We want to give back to the community, and we want to inspire others to give back, too," he said.

Reading the Bottom Line

On one of the inside pages of a children's book Grinspoon loaned to BusinessWest is a handwritten note to the philanthropist from the group for which it was intended.

"Dear Harold: Thanks for making our Jewish libraries so rich," it said.

Like much of Grinspoon's own commentary, the missive was short, yet direct. And it spoke volumes, literally and figuratively.

With those few words, the writer conveyed thanks, but also a statement, that with this program Grinspoon was meeting the primary goal that has guided him in business and in his philanthropy getting a return on investment.

Mexico calls up Franco of Villarreal to play in Ghana friendly

Guillermo Franco, an Argentine-born forward playing for Villarreal in the Spanish league, has been called into Mexico's national team for next week's friendly against Ghana in London.

Mexican national team manager Hugo Sanchez also included Brazilian-born Antonio Naelson, also known as Sinha, for the match on Wednesday.

Sanchez, who will have his status as manager reviewed by Mexican club directors at the end of the month following the country's elimination from Olympic qualifying, had previously said he would try to avoid calling up naturalized foreign-born players.

He specifically criticized his predecessor Ricardo La Volpe for using naturalized players at the 2006 World Cup. Franco played for Mexico in Germany.

Rounding out the big names on the roster are goalkeeper Oswaldo Sanchez and a total of nine players currently playing in European leagues.

___

Roster:

Goalkeepers: Moises Munoz (Morelia), Jose de Jesus Corona (Tecos), Oswaldo Sanchez (Santos).

Defenders: Carlos Salcido (PSV Eindhoven, Netherlands), Ricardo Osorio (Stuttgart, Germany), Aaron Galindo (Frankfurt, Germany), Fausto Pinto (Pachuca), Israel Castro (Pumas), Julio Cesar Dominguez (Cruz Azul).

Midfielder: Pavel Pardo (Stuttgart, Germany), Andres Guardado (Deportivo La Coruna, Spain), Fernando Arce (Santos), Gerardo Torrado (Cruz Azul), Antonio Naelson (Toluca).

Forwards: Antonio Nigris (Ankaraspor, Turkey), Nery Castillo (Manchester City, England), Juan Carlos Cacho (Pachuca), Adolfo Bautista (Jaguares), Carlos Vela (Osasuna, Spain), Guillermo Franco (Villarreal, Spain), Giovani Dos Santos (Barcelona, Spain).

You're Not Really Hungry? Drop That Fork!

Before you eat a meal or a snack or reach for a second helping,halt. Pay attention to your mood.

Are you hungry, angry, lonely or tired?

Many people put on extra pounds because they eat for reasonsother than hunger. In fact, folks often tell me they can't rememberthe last time they were really hungry. They just eat whenever theyfeel like it.

The buffet looks good, so they pile their plates high.

Most people get hungry every four hours if they've eatenreasonable meals, but this differs slightly from person to person.

Some people experience hunger as an emptiness deep inside. Someget restless and lose concentration. Others feel listless, weak,disoriented and uncoordinated. Some don't recognize these symptoms,then become headachy, irritable and short-tempered.

Taste and smell are sharp while you're hungry, but fade as youeat and become satisfied. Food becomes less interesting, evenboring. If you're reading or watching TV while you eat, you may missthese subtle clues to stop.

There's a theory that you'll lose weight if you just cut down onfat. No counting calories. No weighing or measuring food. Eat asmuch as you want, just choose differently.

And that will work if you eat only when hungry and stop whenyou're not hungry anymore.

Eating when you're angry, lonely or tired signals the need forother solutions.

Anger turned inward may become depression, obesity or an eatingdisorder. So before you eat when angry, halt. Confront the rightperson instead. Or at least figure out why you're angry or who isthe true object of your anger. Go for a walk or to a museum. Cooldown, think it through. Don't eat until you get hungry.

Lonely? Halt. Reach for a friend instead of food. Chat with aneighbor or family member. Visit a shut-in. Learn Western, swing orsquare dancing. Join a cycling club or singing group.

"Tired" is often mistaken for "hungry." If you fall into foodat the end of the day and eat like a wild person out of control,halt. Instead, exercise to relieve your stress and boost your energylevels. Take a nap if you need sleep. Delegate chores, if possible.

Reduce your standards for how much you must do. Go have afacial, manicure or massage. Re-evaluate your work load if you'rechronically tired.

Learn to recognize real hunger, so you can enjoy food more.

Learn to recognize other emotions and find appropriate outlets.

Australia ends combat operations in Iraq

Australian troops have ended combat operations in Iraq, a Defense Department official said Saturday.

The Australian flag was lowered in a ceremony Sunday with the 550 troops at a base in the southern Iraq city of Talil. The official spoke on condition of anonymity as required by the Defense Department.

The move fulfills a campaign promise of Prime Minister Kevin Rudd, who was elected last November, to bring the troops home by the middle of this year.

понедельник, 12 марта 2012 г.

Angry mom refuses to bail out teen son

A teenager accused of stealing a pizza delivery guy's car was chewed out by a judge -- and his mom -- Sunday morning in court.

Ravontay Hutchins, 17, allegedly stole the 1996 Acura Integra after the driver left the engine running outside Pompeii, 1531 W. Taylor, at 9:20 p.m. Saturday.

Two cops on a lunch break at the restaurant heard about the theft and quickly put out a description of the stolen car, which the delivery guy was following in another car, police said.

Hutchins and a 14-year-old accomplice were soon arrested after a brief foot chase in the 1300 block of South Albany, prosecutors said.

At a hearing Sunday in Cook County Criminal Court, Hutchins' mother told Judge Peggy Chiampas that Hutchins' father was serving with the military in Iraq and that she'd done everything she could for the boy, who was "spoiled."

When Chiampas set bail at $25,000, his mother said, "I've got [the money to bail him out], but he's staying here, locked up!" and stormed from the courtroom.

Chiampas praised her, saying, "I want to know why there's not more parents like this. . . . I applaud her for her truthfulness."

As Hutchins was led back to the cells, she told him, "You think about that, while your dad's in Iraq."

Hutchins, of the 1200 block of South Throop, faces a felony charge of possession of stolen motor vehicle, a misdemeanor battery charge and several citations.

Comment at suntimes.com.

Finnish man kills 2 adult daughters, wife, self

An 88-year-old man on Sunday killed his two disabled adult daughters and shot his bedridden wife before turning the gun on himself in northern Finland, police said.

The man's wife, also in her 80s, later died at a hospital, police said.

The mentally handicapped daughters, both in their 50s, died immediately from gunshot wounds at home in Ylitornio, about 500 miles north of the capital, Helsinki, police said.

After shooting his daughters, the man went to a local health center and shot his wife before returning home, talking briefly with police on the telephone, and then killing himself, police said.

"He ended the conversation quite soon and then we heard a shot," Ylitornio police chief Seppo Kinnunen said, but gave no details of the conversation.

Police said they knew of no motive and were investigating the case. They declined to give further details.

D.A.: Cop Unjustified in Airman Shooting

SAN BERNARDINO, Calif. - A sheriff's deputy was not justified when he shot and wounded an Iraq war veteran after a high-speed car chase, a prosecutor said Tuesday in closing arguments at the former lawman's trial.

Senior Airman Elio Carrion did not pose a threat to then-Deputy Ivory J. Webb, who shot the serviceman as he appeared to be obeying orders to get up off the ground by the crashed vehicle, said prosecutor Lewis Cope.

"When you look at the totality of the situation, it's not the kind of threat that justified shooting Mr. Carrion," Cope said.

Webb, 46, is charged with attempted voluntary manslaughter and assault with a firearm. He faces more than 18 years in prison if convicted.

In the defense closing argument, attorney Michael Schwartz attacked the prosecution's case, saying a parade of witnesses gave conflicting accounts of what happened and downplayed Carrion's role as a suspect during and after the chase.

"How many bugs do you have to find in the prosecution's case before you throw it out?" Schwartz said.

The shooting occurred Jan. 29, 2006, in Chino, about 40 miles east of Los Angeles, and was recorded on a grainy videotape shot in darkness by an area resident.

Carrion was a passenger in a Corvette that Webb chased at 100 mph and crashed into a wall. Prosecutors dissected the videotape frame-by-frame, outlining how Webb used what they called unreasonable force.

Cope discounted a contention by Webb's attorneys that Carrion reached into his jacket pocket, noting the tape showed the victim's hands were on the ground moments before he was shot.

His hand "never makes it into his jacket," Cope said. "Where is the reason to shoot this man?"

Schwartz said Carrion's hand was near his chest and may have given the appearance that he was reaching for a weapon. "It doesn't matter if he has a weapon. It matters where he puts that hand," Schwartz said.

Schwartz argued that the deputy was worried about controlling the situation, given the circumstances before the shooting, including that Carrion allegedly wasn't complying with Webb's orders. "It was an honest fear. It was a reasonable fear," Schwartz said.

Carrion was shot three times and spent at least a week in a hospital. Cope said Carrion, who is currently on light duty at Barksdale Air Force Base in Louisiana, had a titanium rod put in his leg after the incident.

Earlier in the trial, Carrion testified that he and the driver, Lewis Escobedo, had been drinking that night. The shooting happened after the two men left a barbecue in honor of the airman, who was home after serving a six-month tour in Iraq and was preparing to return to Barksdale.

While Carrion appeared to have difficulty following Webb's orders - often trying to talk over the deputy - it was Webb who did not make good rational decisions during the incident, Cope said.

During the four-week trial, attorneys for Webb, who did not testify, called to the stand three witnesses, including a tactics expert who said the shooting was justified and a forensics alcohol expert who testified about the victim's intoxication level.

The defense was scheduled to conclude final arguments Wednesday.

Woman says she snooped at Spears' home for film

A woman arrested outside Britney Spears' home is a former "American Idol" hopeful who says she's making a paparazzi documentary.

Miranda Tozier-Robbins says she wanted to show the efforts paparazzi go through and she chose Spears because it "might as well be someone I'm interested in."

Deputies arrested the 26-year-old Thursday after security guards caught her peeking into windows at the singer's Calabasas home, wearing camouflage and carrying camera gear.

The Fitchburg, Massachusetts, native responded electronically to a series of questions from The Associated Press on Friday, and confirmed her identity in a phone message. She says she wasn't expecting Spears to be home, but would have tried to sell pictures of the singer if she got any.

Lievremont continues his shake-up of French squad to play England in Six Nations

France coach Marc Lievremont called up fullback Clement Poitrenaud and locks Pascal Pape and Romain Millo-Chluski to his Six Nations squad Wednesday to play England.

Continuing his policy of using the tournament to try out players, Lievremont left out rookie fullback Anthony Floch and locks Loic Jacquet and Arnaud Mela for the Feb. 23 match at Stade de France.

Poitrenaud, who has 31 caps, last played for France against Georgia at the 2007 World Cup.

Pape's last cap, his 18th, came in a 61-10 loss to New Zealand in June. Millo-Chluski has played just one international, a 30-30 draw with South Africa in 2005.

France beat Scotland and Ireland earlier this month and tops the Six Nations standings with Wales.

___

Squad:

Forwards: Julien Brugnaut, Lionel Faure, Nicolas Mas, William Servat, Dimitri Szarzewski, Romain Millo-Chluski, Lionel Nallet, Pascal Pape, Julien Bonnaire, Thierry Dusautoir, Fulgence Ouedraogo, Louis Picamoles.

Backs: Jean-Baptiste Elissalde, Morgan Parra, Francois Trinh-Duc, David Skrela, Damien Traille, David Marty, Vincent Clerc, Aurelien Rougerie, Cedric Heymans, Clement Poitrenaud.

AP-FBC--T25-Mississippi St.-Alabama Stats, FBC

…2064 AP-FBC--T25-Mississippi St.-Alabama Stats

среда, 7 марта 2012 г.

Calendars match lives of owners

A calendar, unlike a diamond, isn't forever. But in today'sdisposable culture, 366 days (1988 is leap year) is quite a while,and what you choose to hang on your wall that long tells a good bitabout you.

The calendars people are choosing to cohabit with for 1988 saythey are becoming more cultured and sophisticated, better masters oftheir time, more responsive to laughter and less to the glamor andexcitement of Hollywood and TV.

They still respond to nature, enjoying the flora and fauna aswell as the sports they watch and indulge in under sun and sky. Andthey are attached to their pets.

They are concerned with self-improvement - in the form of dailythoughts of inspiration, Bible verses and knowledge of plainmiscellaneous trivia.

Although both men and women enjoy the proximity of attractivebodies - or at least printed facsimiles thereof - they insist ondiscretion and taste.

Following are results of an informal survey of what's happeningin 1988 calendar distribution:

The hottest calendar sales are in art scenes, with theImpressionists leading the way. Van Gogh, who never sold a paintingduring his lifetime but whose "Irises" sold a few weeks ago for $53million, is very popular.

High-quality nature scenes are perennial favorites in calendars.Sierra Club, Audubon, National Geographic - both calendars andengagement books published by these old standbys never fail to sell.

Engagement books of all kinds are increasing in popularity. Bigones, little ones, illustrated ones and padded-cover ones are pickingup in sales. "People seem to be more interested in getting control oftheir time," said Mary Sheehan at the Museum Shop of the BaltimoreMuseum of Art.

Garden calendars are popular. Workman Publishing Co. has agiant-sized one called "Garden Pleasures" and others called "FlowersRediscovered" and "Roger Tory Peterson's Birds," illustrated by theman called "the guru of bird-watching.'

Dinosaurs are becoming a fixture in calendar nature. AbbyGildd, at Waldenbooks, said, "Dinosaurs have become trendy. Theystarted with the 5- to 7-year set, but other people have picked up onit."

Skin is still in, in the form of a calendar featuring the annualswimsuit illustrations from Sports Illustrated. But that is aboutthe only cheesecake in calendar sales.

Women, too, have a taste for attractive bodies on their walls.A calendar called "First Impressions" features handsome men that SueAllman of the Baltimore bookstore Greetings and Readings called"stylishly cute." The calendars are bought, she said, by "oldergirls, younger girls - girls of all ages." Another calendar for "acertain kind of girl" is "Fireworks," which depicts "cutefirefighters in a variety of action shots."

In buying next year's calendars, people are thinking about theirfunny bone. There is a calendar called "The Improbable World ofVeteran Outdoorsman Patrick F. McManus Esq." and another on KrazyKat. A Doonesbury calendar is popular with university students.

"Students," said Lisa Pecoraro at the Johns Hopkins UniversityBook Center, "are a good place to look for trends."

Plain bucolic scenes and cute pictures of dogs and cats -the bread and butter of calendar art a few decades back - adorncalendars circulating as freebies.

"Unfortunately, most of them aren't as nice as the ones youbuy," said one observer. "For some reason, the design stopped ataround 1955."

Calendars match lives of owners

A calendar, unlike a diamond, isn't forever. But in today'sdisposable culture, 366 days (1988 is leap year) is quite a while,and what you choose to hang on your wall that long tells a good bitabout you.

The calendars people are choosing to cohabit with for 1988 saythey are becoming more cultured and sophisticated, better masters oftheir time, more responsive to laughter and less to the glamor andexcitement of Hollywood and TV.

They still respond to nature, enjoying the flora and fauna aswell as the sports they watch and indulge in under sun and sky. Andthey are attached to their pets.

They are concerned with self-improvement - in the form of dailythoughts of inspiration, Bible verses and knowledge of plainmiscellaneous trivia.

Although both men and women enjoy the proximity of attractivebodies - or at least printed facsimiles thereof - they insist ondiscretion and taste.

Following are results of an informal survey of what's happeningin 1988 calendar distribution:

The hottest calendar sales are in art scenes, with theImpressionists leading the way. Van Gogh, who never sold a paintingduring his lifetime but whose "Irises" sold a few weeks ago for $53million, is very popular.

High-quality nature scenes are perennial favorites in calendars.Sierra Club, Audubon, National Geographic - both calendars andengagement books published by these old standbys never fail to sell.

Engagement books of all kinds are increasing in popularity. Bigones, little ones, illustrated ones and padded-cover ones are pickingup in sales. "People seem to be more interested in getting control oftheir time," said Mary Sheehan at the Museum Shop of the BaltimoreMuseum of Art.

Garden calendars are popular. Workman Publishing Co. has agiant-sized one called "Garden Pleasures" and others called "FlowersRediscovered" and "Roger Tory Peterson's Birds," illustrated by theman called "the guru of bird-watching.'

Dinosaurs are becoming a fixture in calendar nature. AbbyGildd, at Waldenbooks, said, "Dinosaurs have become trendy. Theystarted with the 5- to 7-year set, but other people have picked up onit."

Skin is still in, in the form of a calendar featuring the annualswimsuit illustrations from Sports Illustrated. But that is aboutthe only cheesecake in calendar sales.

Women, too, have a taste for attractive bodies on their walls.A calendar called "First Impressions" features handsome men that SueAllman of the Baltimore bookstore Greetings and Readings called"stylishly cute." The calendars are bought, she said, by "oldergirls, younger girls - girls of all ages." Another calendar for "acertain kind of girl" is "Fireworks," which depicts "cutefirefighters in a variety of action shots."

In buying next year's calendars, people are thinking about theirfunny bone. There is a calendar called "The Improbable World ofVeteran Outdoorsman Patrick F. McManus Esq." and another on KrazyKat. A Doonesbury calendar is popular with university students.

"Students," said Lisa Pecoraro at the Johns Hopkins UniversityBook Center, "are a good place to look for trends."

Plain bucolic scenes and cute pictures of dogs and cats -the bread and butter of calendar art a few decades back - adorncalendars circulating as freebies.

"Unfortunately, most of them aren't as nice as the ones youbuy," said one observer. "For some reason, the design stopped ataround 1955."

Calendars match lives of owners

A calendar, unlike a diamond, isn't forever. But in today'sdisposable culture, 366 days (1988 is leap year) is quite a while,and what you choose to hang on your wall that long tells a good bitabout you.

The calendars people are choosing to cohabit with for 1988 saythey are becoming more cultured and sophisticated, better masters oftheir time, more responsive to laughter and less to the glamor andexcitement of Hollywood and TV.

They still respond to nature, enjoying the flora and fauna aswell as the sports they watch and indulge in under sun and sky. Andthey are attached to their pets.

They are concerned with self-improvement - in the form of dailythoughts of inspiration, Bible verses and knowledge of plainmiscellaneous trivia.

Although both men and women enjoy the proximity of attractivebodies - or at least printed facsimiles thereof - they insist ondiscretion and taste.

Following are results of an informal survey of what's happeningin 1988 calendar distribution:

The hottest calendar sales are in art scenes, with theImpressionists leading the way. Van Gogh, who never sold a paintingduring his lifetime but whose "Irises" sold a few weeks ago for $53million, is very popular.

High-quality nature scenes are perennial favorites in calendars.Sierra Club, Audubon, National Geographic - both calendars andengagement books published by these old standbys never fail to sell.

Engagement books of all kinds are increasing in popularity. Bigones, little ones, illustrated ones and padded-cover ones are pickingup in sales. "People seem to be more interested in getting control oftheir time," said Mary Sheehan at the Museum Shop of the BaltimoreMuseum of Art.

Garden calendars are popular. Workman Publishing Co. has agiant-sized one called "Garden Pleasures" and others called "FlowersRediscovered" and "Roger Tory Peterson's Birds," illustrated by theman called "the guru of bird-watching.'

Dinosaurs are becoming a fixture in calendar nature. AbbyGildd, at Waldenbooks, said, "Dinosaurs have become trendy. Theystarted with the 5- to 7-year set, but other people have picked up onit."

Skin is still in, in the form of a calendar featuring the annualswimsuit illustrations from Sports Illustrated. But that is aboutthe only cheesecake in calendar sales.

Women, too, have a taste for attractive bodies on their walls.A calendar called "First Impressions" features handsome men that SueAllman of the Baltimore bookstore Greetings and Readings called"stylishly cute." The calendars are bought, she said, by "oldergirls, younger girls - girls of all ages." Another calendar for "acertain kind of girl" is "Fireworks," which depicts "cutefirefighters in a variety of action shots."

In buying next year's calendars, people are thinking about theirfunny bone. There is a calendar called "The Improbable World ofVeteran Outdoorsman Patrick F. McManus Esq." and another on KrazyKat. A Doonesbury calendar is popular with university students.

"Students," said Lisa Pecoraro at the Johns Hopkins UniversityBook Center, "are a good place to look for trends."

Plain bucolic scenes and cute pictures of dogs and cats -the bread and butter of calendar art a few decades back - adorncalendars circulating as freebies.

"Unfortunately, most of them aren't as nice as the ones youbuy," said one observer. "For some reason, the design stopped ataround 1955."

Kvitova, Berdych lead Czechs to 2-0 Hopman Cup win

PERTH, Australia (AP) — Wimbledon champion Petra Kvitova and teammate Tomas Berdych won their singles matches Monday to give Czech Republic a 2-0 win over Bulgaria at the Hopman Cup.

Kvitova won the last five games of her match to beat Tsvetana Pironkova 6-4, 6-2 before seventh-ranked Berdych defeated Grigor Dimitrov 6-4, 6-7 (8), 6-3.

The …

вторник, 6 марта 2012 г.

Factory Orders Fall in August

WASHINGTON - Orders to U.S. factories fell in August by the largest amount in seven months, reflecting weakness across a wide swath of manufacturing.

The Commerce Department said that orders dropped by 3.3 percent last month, even worse than the 2.8 percent decline that had been expected. It was the biggest setback since orders fell 4.2 percent in January.

The fall-off was led by a huge plunge in demand for commercial aircraft, which fell by 39.9 percent. However, orders were also weak in a number of other industries, from autos to industrial machinery and home appliances.

THIS IS A BREAKING NEWS UPDATE. Check back soon for further information. AP's earlier story is below.

WASHINGTON (AP) - The number of newly laid off workers filing claims for unemployment benefits shot up last week by the biggest amount in four months.

The Labor Department reported a total of 317,000 applications for unemployment benefits last week, an increase of 16,000 from the previous week. It was the biggest gain since jobless claims rose by 18,000 during the week of May 9.

The rise was bigger than analysts had been expecting and could be a further sign that the labor market is slowing under the impact of the worst slump in housing in 16 years and a severe credit crunch that roiled global markets in August.

Labor Department analysts said that the two-day auto strike involving General Motors Corp. did not appear to have a significant impact on the claims figures last week, according to preliminary information from the states.

The increase in claims last week followed two weeks of declines. The four-week average for claims totaled 312,750, up only slightly from the previous week.

Analysts believe the unemployment rate probably rose in September to 4.7 percent, up from 4.6 percent in August, although they are expecting that businesses added 100,000 jobs to their payrolls.

That would be an improvement from the net loss of 4,000 jobs in August, which had been the first monthly job loss in four years. The employment data for September will be released on Friday.

The unemployment report is being closely followed by Wall Street, where investors believe it will provide the key piece of data the Federal Reserve will need to decide whether to cut interest rates further.

After the surprisingly bad August jobs report was released, the Fed decided to cut a key interest rate for the first time in four years, reducing it by a larger-than-expected half-point.

Many economists believe aggressive Fed action is needed to keep the economy from sliding into a recession. Overall economic growth is expected to have slowed to around 2.5 percent in the July-September quarter with a further decrease to 2 percent or less expected in the current quarter.

Former Federal Reserve Chairman Alan Greenspan, who put the risks of a recession at about 30 percent at the beginning of the year, has said more recently that the steep housing slump and financial market turmoil in August have pushed that chance up although he said the risk still remain below 50 percent.

понедельник, 5 марта 2012 г.

OCCUPIED MIND

OCCUPIED MIND PALESTINIAN WALKS: FORAYS INTO A VANISHING LANDSCAPE BY RAJA SHEHADEH NEW YORK: SCRIBNER. 224 PAGES. $15.

A lawyer by training and a writer by necessity, Raja Shehadeh has, since the early '80s, argued cases of Palestinian land ownership in Israeli courts and written extensively on the legal aspects of the occupation of the West Bank and Gaza. He has also produced five volumes of prose about Palestinian life, of which Strangers in the House: Coming of Age in Occupied Palestine (2001 ) is the best known to American readers. Part memoir, part family chronicle, the book is an emotionally fraught intergenerational narrative about growing up in the shadow of the …

Sweden's economic sentiment improves in May 2011.

(ADPnews) - May 26, 2011 - Sweden's economic tendency indicator (ETI), which measures the sentiment of businesses and households, rose to 112.4 points in May 2011 from a revised 110.4 points in the preceding month.

Analysts polled by SME Direkt had on average expected a marginal decline to 109.7 points.

This month's …

Cain very able vs. Angels; Giants rookie right-hander takes no-hit bid into eighth.(Sports)

Byline: Associated Press

SAN FRANCISCO - Rookie Matt Cain carried a no-hitter into the eighth inning, Barry Bonds hit an RBI double, and the San Francisco Giants ended a three-game losing streak with a 2-1 victory over the Los Angeles Angels on Monday night.

Chone Figgins lined a clean single to center on Cain's 128th pitch of the game with two outs in the eighth to end the longest no-hit bid in the majors this year. Carlos Zambrano of the Chicago Cubs no-hit the Houston Astros for 71/3 innings earlier this month.

Cain struck out a career-high 10 batters on the way to winning his fifth straight decision, striking out the side in the seventh as the …

Preserving the Living Past: John C. Merriam's Legacy in the State and National Parks.(Crow's Range: An Environmental History of the Sierra Nevada)(Book review)

PRESERVING THE LIVING PAST: John C. Merriam's Legacy in the State and National Parks

By Stephen R. Mark (Berkeley: University of California Press, 2005, 204 pp., cloth, $39.95)

CROW'S RANGE: An Environmental History of the Sierra Nevada

By David Beesley (Reno: University of Nevada Press, 2004, 390 pp., cloth $39.95)

John Muir called the Sierra Nevada mountain chain, the "Range of Light." John C. Merriam believed that such beautiful, magnificent, natural features could inspire and educate people, achieving another form of "light." These volumes, well-written and extensively researched, offer fascinating insight into complimentary subjects: …